ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
-
ADC Payloads
(215)
View all products
-
Auristatin
(15)
View all products
-
Calicheamicins
(1)
View all products
-
Camptothecins
(42)
View all products
-
Daunorubicins/
Doxorubicins (11)View all products
-
Duocarmycins
(18)
View all products
-
Maytansinoids
(10)
View all products
-
Pyrrolobenzodiazepines
(8)
View all products
-
Traditional Cytotoxic Agents
(24)
View all products
All Product Categories
-
ADC Payloads Related Products (368)
Related Products (368)
-
Antibodies (2)
-
Related Compound Screening Libraries (1)
-
ADC Payloads Isoform Comparison
-
Dolastatin 15
0 ImagesCat. No.: HY-P1126CAS No.: 123884-00-4Synonyms: DLS 15Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin.
-
SGD-1882-Dap-Val
0 ImagesCat. No.: HY-148760CAS No.: 2057431-94-2SGD-1882-Dap-Val is an intermediate compound. SGD-1882-Dap-Val can be used in the synthesis of antibody-drug conjugates (ADCs).
-
(1R,9S)-Exatecan
0 ImagesCat. No.: HY-13631TCAS No.: 2231666-57-0Synonyms: (1R,9S)-DX-8951(1R,9S)-Exatecan (DX8951) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
-
Eg5-IN-2
0 ImagesCat. No.: HY-157078CAS No.: 1629735-05-2Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC50: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs.
-
Auristatin S
0 ImagesCat. No.: HY-164107CAS No.: 3028453-70-2Auristatin S is a potent Auristatin payload. Auristatin S binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.
-
Seco-Duocarmycin SA
0 ImagesCat. No.: HY-129356CAS No.: 144667-38-9Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates.
-
Glucocorticoid receptor agonist-6
0 ImagesCat. No.: HY-171081CAS No.: 2117643-80-6Glucocorticoid receptor agonist-6 (Compound A) is a Glucocorticoid receptor (GR) agonist. Glucocorticoid receptor agonist-6 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
-
DMEA-PNU-159682 dichloroacetate
0 ImagesCat. No.: HY-126665ACAS No.: 1799421-49-0DMEA-PNU-159682 (molecule D12) dichloroacetate is an ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682.
-
NVP-BQS481
0 ImagesCat. No.: HY-177285CAS No.: 1161925-41-2NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
-
Pan-RAS-IN-9-(R)-2-Hydroxy-3-methylbutanoic acid
0 ImagesCat. No.: HY-186278CAS No.: 3122549-15-6Pan-RAS-IN-9-(R)-2-Hydroxy-3-methylbutanoic acid is a potent payload for ADC (ADC payload) with pan-inhibitory activity against Ras.
-
Tubulysin E
0 ImagesCat. No.: HY-N2346CAS No.: 309935-58-8Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis.
-
Exatecan analog 38
0 ImagesCat. No.: HY-178315CAS No.: 2766214-00-8Exatecan analog 38 is a camptothecin derivative with potent topoisomerase I inhibitory activity. Exatecan analog 38 can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Exatecan analog 38 can be used for cancer research.
-
Bac5(1-25)
0 ImagesCat. No.: HY-P5748CAS No.: 170917-43-8Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5.
-
ε-Amanitin
0 ImagesCat. No.: HY-131083CAS No.: 21705-02-2ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.
-
Ansamitocin P-3 (Standard)
0 ImagesCat. No.: HY-15739RCAS No.: 66584-72-3Synonyms: Antibiotic C 15003P3 (Standard); Maytansinol isobutyrate (Standard)Ansamitocin P-3 (Standard) is the analytical standard of Ansamitocin P-3. This product is intended for research and analytical applications. Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
-
Gly-Cyclopropane-Exatecan
0 ImagesCat. No.: HY-148696ACAS No.: 2414254-49-0Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro.
-
Nampt-IN-13
0 ImagesCat. No.: HY-164759CAS No.: 2592504-89-5Nampt-IN-13 is a NAMPT inhibitor that serves as a payload for the synthesis of ADCs. Nampt-IN-13 is applicable to cancer-related research.
-
Mensacarcin
0 ImagesCat. No.: HY-122534CAS No.: 808750-39-2Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
-
Tubulysin IM-2
0 ImagesCat. No.: HY-130959CAS No.: 1032072-50-6Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.
